Infections at any age are discomforting and potentially life-threatening. For older adults, infections may lead to complications for existing complex health conditions, chronic discomfort and poor health, and a greater risk of hospitalization or even death. One in three deaths of persons over the age of 65 is directly associated with an infectious disease. Symptoms and diagnosis are often more difficult because the typical signs can be misread or not frequently observed. A sudden change in mental status or decline in physical function may be the only visible sign in an older patient with an infection.